| |
Article Title |
Author(s) |
Type (Status) |
Available Online |
|
The role of inflammation in health and disease: Translating discovery into novel therapeutic approaches
DOI: 10.1016/j.trsl.2012.05.002
The 2012 Combined Annual Meeting of the Central Society for Clinical Research and the Midwestern Section American Federation for Medical Research was held April 26 to 27 in Chicago, Illinois. The Cent...
|
Neal L. Weintraub
|
News
(In Press Uncorrected Proof)
|
21 May 2012 |
|
Functional analysis of the novel sequence variants within TBX5 gene promoter in patients with ventricular septal defects
DOI: 10.1016/j.trsl.2012.04.003
Congenital heart disease (CHD) is the most common birth defect that affects 1% to 2% of human live births. Despite advanced surgical treatment, adult patients with CHD are predisposed to late cardiac ...
|
Jiping Shan,
Shuchao Pang,
Yanli Qiao,
Liming Ma,
Haihua Wang,
Qining Xing,
Hongxin Wanyan,
Guanghua Wu,
Bo Yan
et al.
|
Short communication
(In Press Uncorrected Proof)
|
14 May 2012 |
|
Vascular endothelial growth factor and uPA/suPAR system in early and advanced chronic kidney disease patients: a new link between angiogenesis and hyperfibrinolysis?
DOI: 10.1016/j.trsl.2012.04.004
Disturbances in hemostasis and abnormal angiogenesis are components in the plaque growth and destabilization. The role of the vascular endothelial growth factor (VEGF) in the perturbation of hemostasi...
|
Krystyna Pawlak,
Blanka Ulazka,
Michal Mysliwiec,
Dariusz Pawlak
|
Full-length article
(In Press Uncorrected Proof)
|
10 May 2012 |
|
Circulating microRNAs as candidate biomarkers in patients with systemic lupus erythematosus
DOI: 10.1016/j.trsl.2012.04.002
Aberrant expression of microRNAs (miRNAs) has been identified in various diseases. Recent studies demonstrated that miRNAs can be detected in the circulation and serve as potential biomarkers of vario...
|
Honglei Wang,
Wujian Peng,
Xin Ouyang,
Wuxian Li,
Yong Dai
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
07 May 2012 |
|
Erratum
DOI: 10.1016/j.trsl.2012.04.001
Giuseppina Novo, Francesco Cappello, Manfredi Rizzo, Giovanni Fazio, Sabrina Zambuto, Enza Tortorici, Antonella Marino Gammazza, Simona Corrao, Giovanni Zummo, Everly C. De Macario, Alberto JL Macario...
|
|
Erratum
(In Press Uncorrected Proof)
|
25 April 2012 |
|
Emerging view of the human virome
DOI: 10.1016/j.trsl.2012.03.006
The human virome is the collection of all viruses that are found in or on humans, including both eukaryotic and prokaryotic viruses. Eukaryotic viruses clearly have important effects on human health, ...
|
Kristine M. Wylie,
George M. Weinstock,
Gregory A. Storch
|
Review article
(In Press Uncorrected Proof)
|
25 April 2012 |
|
The clinical and immunologic features of pulmonary fibrosis in sarcoidosis
DOI: 10.1016/j.trsl.2012.03.005
Sarcoidosis is a multisystem, granulomatous disease that most often affects the lungs. The clinical course is highly variable; many patients undergo spontaneous remission, but up to a third of patient...
|
Karen C. Patterson,
Kyle Hogarth,
Aliya N. Husain,
Anne I. Sperling,
Timothy B. Niewold
et al.
|
Review article
(In Press Uncorrected Proof)
|
11 April 2012 |
|
Glomerular basement membrane and related glomerular disease
DOI: 10.1016/j.trsl.2012.03.004
The glomerular basement membrane (GBM) is lined by fenestrated endothelium from the capillary-lumen side and by interdigitating foot processes of the podocytes from the urinary- space side. These thre...
|
Ying Maggie Chen,
Jeffrey H. Miner
|
Review article
(In Press Uncorrected Proof)
|
11 April 2012 |
|
Participation of endoplasmic reticulum stress in the pathogenesis of spontaneous glomerulosclerosis–Role of intra-renal angiotensin system
DOI: 10.1016/j.trsl.2012.03.003
Endoplasmic reticulum (ER) is the site of synthesis, folding, assembly, and degradation of proteins. Disruption of ER function leads to ER stress, which is marked by accumulation of unfolded proteins ...
|
Mohammad A. Aminzadeh,
Tadashi Sato,
Nosratola D. Vaziri
|
Full-length article
(In Press Uncorrected Proof)
|
09 April 2012 |
|
Influence of hepatic and intestinal efflux transporters and their genetic variants on the pharmacokinetics and pharmacodynamics of raloxifene in osteoporosis treatment
DOI: 10.1016/j.trsl.2012.03.002
Raloxifene exhibits a large and unexplained interindividual variability in its pharmacokinetics and pharmacodynamics. The aim of our study was to identify transporters involved in the efflux of raloxi...
|
Tina Trdan Lušin,
Aleš Mrhar,
Bruno Stieger,
Gerd A. Kullak-Ublick,
Janja Marc,
Barbara Ostanek,
Andrej Zavratnik,
Albin Kristl,
Katja Berginc,
Katja Delić,
Jurij Trontelj
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
29 March 2012 |
|
Miniaturized technology for protein and nucleic acid point-of-care testing
DOI: 10.1016/j.trsl.2012.02.012
The field of point-of-care (POC) testing technology is developing quickly and producing instruments that are increasingly reliable, while their size is being gradually reduced. Proteins are a common t...
|
Felix Olasagasti,
Juan Carlos Ruiz de Gordoa
|
Review article
(In Press Uncorrected Proof)
|
12 March 2012 |
|
Understanding vaginal microbiome complexity from an ecological perspective
DOI: 10.1016/j.trsl.2012.02.008
The various microbiota normally associated with the human body have an important influence on human development, physiology, immunity, and nutrition. This is certainly true for the vagina wherein comm...
|
Roxana J. Hickey,
Xia Zhou,
Jacob D. Pierson,
Jacques Ravel,
Larry J. Forney
et al.
|
Review article
(In Press Uncorrected Proof)
|
07 March 2012 |
|
The Gly460Trp polymorphism of alpha-adducin gene as a predictor of renal function decline over 4 years of follow-up in an apparently healthy Chinese population
DOI: 10.1016/j.trsl.2012.01.006
A large epidemiologic study showed that subjects with reduced renal function, defined as a glomerular filtration rate (GFR) less than 60 mL/min/1.73 m2, are at risk for the development of end-stage re...
|
Tsung-Hsien Lin,
Herng-Chia Chiu,
Chiao-Ling Wang,
Po-Chao Hsu,
Ho-Ming Su,
Wen-Chol Voon,
Wen-Ter Lai,
Sheng-Hsiung Sheu
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
05 March 2012 |
|
Pretransplant IFN-γ ELISPOT assay as a potential screening test to select immunosuppression protocols for patients receiving basiliximab induction therapy
DOI: 10.1016/j.trsl.2012.02.009
The use of basiliximab induction therapy has increased in standard immunological risk patients. The objective of this study was to identify whether pretransplant donor-reactive interferon-γ enzyme-lin...
|
Yonggoo Kim,
Ki-Hyun Park,
Byung Ha Chung,
Bum-Soon Choi,
Chul Woo Yang,
Ji-il Kim,
In-Sung Moon,
Yeon-Joon Park,
Kyungja Han,
Eun-Jee Oh
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
05 March 2012 |
|
Therapeutic window of taurine against experimental stroke in rats
DOI: 10.1016/j.trsl.2012.02.007
The dose-dependent protection of taurine against experimental stroke has been demonstrated previously. The objective of this study was to investigate the therapeutic window of taurine against experime...
|
Ming Sun,
Yu-Mei Zhao,
Yi Gu,
Chao Xu
|
Full-length article
(In Press Uncorrected Proof)
|
02 March 2012 |
|
The microbiome of the lung
DOI: 10.1016/j.trsl.2012.02.005
Investigation of the lung microbiome is a relatively new field. Although the lungs were classically believed to be sterile, recently published investigations have identified microbial communities in t...
|
James M. Beck,
Vincent B. Young,
Gary B. Huffnagle
|
Review article
(In Press Uncorrected Proof)
|
29 February 2012 |
|
Pioglitazone, a PPAR-γ activator, attenuates the severity of cerulein-induced acute pancreatitis by modulating early growth response-1 transcription factor
DOI: 10.1016/j.trsl.2012.02.003
The purpose of this study was to test the hypothesis that activation of endogenous peroxisome proliferator-activated receptor (PPARγ) inhibits induction of early growth response factor-1 (Egr-1), whic...
|
Hongyu Wan,
Yaozong Yuan,
Jiansheng Liu,
Guohong Chen
|
Full-length article
(In Press Uncorrected Proof)
|
29 February 2012 |
|
Human umbilical cord blood mononuclear cells activate the survival protein Akt in cardiac myocytes and endothelial cells that limits apoptosis and necrosis during hypoxia
DOI: 10.1016/j.trsl.2012.02.004
We have previously reported that human umbilical cord blood mononuclear cells (HUCBC), which contain hematopoietic, mesenchymal, and endothelial stem cells, can significantly reduce acute myocardial i...
|
Robert J. Henning,
Steve Dennis,
Darrell Sawmiller,
Lorynn Hunter,
Paul Sanberg,
Leslie Miller
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
29 February 2012 |
|
Future directions and treatment strategies for head and neck squamous cell carcinomas
DOI: 10.1016/j.trsl.2012.02.002
Head and neck cancer is a devastating disease that afflicts many individuals worldwide. Conventional therapies are successful in only a limited subgroup and often leave the patient with disfigurement ...
|
Trisha M. Wise-Draper,
David J. Draper,
J. Silvio Gutkind,
Alfredo A. Molinolo,
Kathryn A. Wikenheiser-Brokamp,
Susanne I. Wells
et al.
|
Review article
(In Press Uncorrected Proof)
|
29 February 2012 |
|
Erratum
DOI: 10.1016/j.trsl.2012.02.011
Cary Stelloh, Kenneth P. Allen, David L. Mattson, Alexandra Lerch-Gaggl, Sreenivas Reddy, and Ashraf El-Meanawy
|
|
Erratum
(In Press Uncorrected Proof)
|
27 February 2012 |
|
Accelerated cellular senescence in the kidney: Cause or effect of disease progression?
DOI: 10.1016/j.trsl.2012.02.006
Structure and function are intimately connected in biological systems. When the structural integrity of cells, tissues, and organs is compromised, then physiologic function declines or completely stop...
|
Carrie L. Phillips
|
Discussion
(In Press Uncorrected Proof)
|
27 February 2012 |
|
Cantharidin-induced inflammation in mouse ear model for translational research of novel anti-inflammatories
DOI: 10.1016/j.trsl.2012.02.001
The murine model of cantharidin-induced ear inflammation was profiled in detail for its alignment with the human model and to explore the mechanism of anti-inflammatory activity of the macrolide antib...
|
Vanesa Ivetic Tkalcevic,
Boska Hrvacic,
Martina Bosnar,
Snjezana Cuzic,
Berislav Bosnjak,
Vesna Erakovic Haber,
Ines Glojnaric
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
27 February 2012 |
|
Biochemical dynamics relevant to the safety of low-dose, intraclot alteplase for deep vein thrombosis
DOI: 10.1016/j.trsl.2012.01.025
Intraclot tissue plasminogen activator (tPA) has been shown to be an effective treatment for deep vein thrombosis (DVT) (Radiology 2008;246:619 and J Vasc Interv Radiol 2011;22:1107). We sought to cor...
|
Jay Nelson Lozier,
Ann Cullinane,
Khanh Nghiem,
Richard Chang,
Mcdonald K. Horne
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
24 February 2012 |
|
Blockade of electron transport before ischemia protects mitochondria and decreases myocardial injury during reperfusion in aged rat hearts
DOI: 10.1016/j.trsl.2012.01.024
Myocardial injury is increased in the aged heart following ischemia and reperfusion (I-R) in both humans and experimental models. Hearts from aged 24-month-old Fischer 344 rats sustain greater cell de...
|
Christine Tanaka-Esposito,
Qun Chen,
Edward J. Lesnefsky
|
Full-length article
(In Press Uncorrected Proof)
|
20 February 2012 |
|
Author reply
DOI: 10.1016/j.trsl.2012.01.017
We appreciate Dr. Firneisz’s interest and comments on our article, as well as pointing out our careless error to us and the readers. As they indicated, our statement that there was a negative correlat...
|
Yoshimasa Aso
|
Correspondence
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Serum level of soluble CD26/dieptidyl peptidase-4 (DPP-4) activity correlates with other liver disease biomarkers both in Asian and European patients. Higher doses of DPP-4 inhibitors (more than 50 mg daily sitagliptin) or loss of 4 kg bodyweight with a strict supervised diet are required in those patients with type 2 diabetes mellitus who also present with nonalcoholic fatty liver disease (NAFLD)
DOI: 10.1016/j.trsl.2012.01.016
We read with great interest the online paper titled: “Serum level of soluble CD26/dipeptidyl peptidase-4 (DPP-4) predicts the response to sitagliptin, a DPP-4 inhibitor, in patients with type 2 diabet...
|
Gabor Firneisz,
Aniko Somogyi
|
Correspondence
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Pathogenesis of pre-eclampsia: marinobufagenin and angiogenic imbalance as biomarkers of the syndrome
DOI: 10.1016/j.trsl.2012.01.005
Pre-eclampsia (preE), a pregnancy disorder with the de novo onset of hypertension and proteinuria after 20 weeks of gestation, has multiple triggers that initiate pathophysiologic mechanisms. This rev...
|
M. Nasir Uddin,
Steven R. Allen,
Richard O. Jones,
David C. Zawieja,
Thomas J. Kuehl
et al.
|
Review article
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Relationship between adipokines and coronary artery aneurysm in children with Kawasaki disease
DOI: 10.1016/j.trsl.2012.01.013
Body fat is an important source of adipokines not only in association with energy balance, but also with inflammatory and immune responses. This study investigated the relationship between serum level...
|
Ruixi Liu,
Bo He,
Fang Gao,
Qian Liu,
Qijian Yi
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Tanshinone II-A inhibits oxidized LDL-induced LOX-1 expression in macrophages by reducing intracellular superoxide radical generation and NF-κB activation
DOI: 10.1016/j.trsl.2012.01.008
Lectin-like oxidized LDL (oxLDL) receptor-1 (LOX-1), a novel scavenger receptor highly expressed in human and experimental atherosclerotic lesions, is responsible for the uptake of oxLDL in vascular c...
|
Suowen Xu,
Zhiping Liu,
Yan Huang,
Kang Le,
Futian Tang,
Heqing Huang,
Sayoko Ogura,
Peter J. Little,
Xiaoyan Shen,
Peiqing Liu
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Serum levels of proprotein convertase subtilisin/kexin type 9 in subjects with familial hypercholesterolemia indicate that proprotein convertase subtilisin/kexin type 9 is cleared from plasma by low-density lipoprotein receptor–independent pathways
DOI: 10.1016/j.trsl.2012.01.010
Secreted proprotein convertase subtilisin/kexin type 9 (PCSK9) binds to the low-density lipoprotein receptor (LDLR) at the cell surface and disrupts the normal recycling of the LDLR. When human PCSK9 ...
|
Jamie Cameron,
Martin P. Bogsrud,
Kristian Tveten,
Thea Bismo StrØm,
Kirsten Holven,
Knut Erik Berge,
Trond P. Leren
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Identifying and exploiting defects in the Fanconi anemia/BRCA pathway in oncology
DOI: 10.1016/j.trsl.2012.01.022
Defects in components of DNA repair pathways are responsible for numerous hereditary cancer syndromes and are also common in many sporadic malignancies. Inherited mutations in the breast cancer suscep...
|
Shane R. Stecklein,
Roy A. Jensen
|
Review article
(In Press Uncorrected Proof)
|
10 February 2012 |
|
An inflammation-based prognostic index predicts survival advantage after transarterial chemoembolization in hepatocellular carcinoma
DOI: 10.1016/j.trsl.2012.01.011
Transarterial chemoembolization (TACE) is the preferred treatment for unresectable, intermediate-stage hepatocellular carcinoma (HCC). However, survival after TACE can be highly variable, suggesting t...
|
David J. Pinato,
Rohini Sharma
|
Full-length article
(In Press Uncorrected Proof)
|
10 February 2012 |
|
Translational research in infectious disease: current paradigms and challenges ahead
DOI: 10.1016/j.trsl.2011.12.009
In recent years, the biomedical community has witnessed a rapid scientific and technologic evolution after the development and refinement of high-throughput methodologies. Concurrently and consequenti...
|
Judith M. Fontana,
Elizabeth Alexander,
Mirella Salvatore
|
Review article
(In Press Uncorrected Proof)
|
16 January 2012 |
|
Treating hepatitis C infection by targeting the host
DOI: 10.1016/j.trsl.2011.12.007
More than 130 million people worldwide are chronically infected with the hepatitis C virus (HCV), which can lead to cirrhosis, liver failure, and hepatocellular carcinoma. Although recently approved H...
|
Shadi Salloum,
Andrew W. Tai
|
Review article
(In Press Uncorrected Proof)
|
11 January 2012 |
|
Effect of oxidative stress and endotoxin on human serum albumin in brain-dead organ donors
DOI: 10.1016/j.trsl.2011.12.005
Albumin, among other molecules, binds and detoxifies endotoxin in healthy people. Oxidative stress leads to protein oxidation and thus to the impaired binding properties of albumin. This property, in ...
|
Bettina Leber,
Vanessa Stadlbauer,
Philipp Stiegler,
Stefanie Stanzer,
Ursula Mayrhauser,
Sonja Koestenbauer,
Barbara Leopold,
Michael Sereinigg,
Andreas Puntschart,
Tatjana Stojakovic,
Karl-Heinz Tscheliessnigg,
Karl Oettl
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
09 January 2012 |
|
Silibinin modulates lipid homeostasis and inhibits nuclear factor kappa B activation in experimental nonalcoholic steatohepatitis
DOI: 10.1016/j.trsl.2011.12.003
Nonalcoholic steatohepatitis (NASH) is associated with increased liver-related mortality. Disturbances in hepatic lipid homeostasis trigger oxidative stress and inflammation (ie, lipotoxicity), leadin...
|
Federico Salamone,
Fabio Galvano,
Francesco Cappello,
Andrea Mangiameli,
Ignazio Barbagallo,
Giovanni Li Volti
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
04 January 2012 |
|
Accelerated senescence of renal tubular epithelial cells is associated with disease progression of patients with immunoglobulin A (IgA) nephropathy
DOI: 10.1016/j.trsl.2011.11.008
The aim of this study is to determine the potential correlation between the accelerated senescence of renal tubular epithelial cells (RTECs) and the disease progression of patients with immunoglobulin...
|
Jun Liu,
Ju-Rong Yang,
Ya-Ni He,
Jian-Guo Zhang,
Li-Rong Lin,
Jun Zhan,
Jin-Hua Zhang,
Hua-Shi Xiao
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
28 December 2011 |
|
Inflammatory bowel disease and pregnancy: overlapping pathways
DOI: 10.1016/j.trsl.2011.12.002
Several studies have reported on the association between inflammatory bowel disease (IBD) and adverse pregnancy outcomes, such as preterm birth. The exact mechanisms of action are unclear; however, se...
|
Noha Ahmed Nasef,
Lynnette R. Ferguson
|
Review article
(In Press Uncorrected Proof)
|
26 December 2011 |
|
Reply to “Intracardiac T-wave alternans, ischemia, and arrhythmias, in a canine model”
DOI: 10.1016/j.trsl.2011.11.004
We appreciate the interest in the article on T-wave alternans (TWA) and arrhythmia. The issues of interest that were raised in the initial letter to the editor are addressed in the following paragraph...
|
Michael A. Kwofie,
James B. Martins
|
Correspondence
(In Press Uncorrected Proof)
|
12 December 2011 |
|
Single-nucleotide polymorphisms in inflammatory bowel disease
DOI: 10.1016/j.trsl.2011.10.006
Strong evidence indicates that inflammatory bowel disease, including Crohn disease and ulcerative colitis, is a result of an inappropriate inflammatory response in which genetic and environmental fact...
|
Manuela G. Neuman,
Radu M. Nanau
|
Review article
(In Press Uncorrected Proof)
|
24 November 2011 |
|
Genetic origin and interaction of the Filipino β0-thalassemia with Hb E and α-thalassemia in a Thai family
DOI: 10.1016/j.trsl.2011.10.008
We describe hematologic and molecular characteristics of a hitherto undescribed interaction between the Filipino deletional β0-thalassemia with Hb E and α-thalassemia in a Thai family. This study was ...
|
Supawadee Yamsri,
Kanokwan Sanchaisuriya,
Goonnapa Fucharoen,
Supan Fucharoen
|
Full-length article
(In Press Uncorrected Proof)
|
18 November 2011 |
|
Chronic inflammation and pain in a tumor necrosis factor receptor (TNFR) (p55/p75-/-) dual deficient murine model
DOI: 10.1016/j.trsl.2011.10.003
Many aspects of tissue damage after acute or chronic inflammatory reactions can be attributed directly to the concomitant biosynthesis and release of inducible early proinflammatory cytokine tumor nec...
|
Karin W. Westlund,
Liping Zhang,
Fei Ma,
Helieh S. Oz
|
Full-length article
(In Press Uncorrected Proof)
|
10 November 2011 |
|
Erythromycin ameliorates cigarette-smoke–induced emphysema and inflammation in rats
DOI: 10.1016/j.trsl.2011.09.007
The exposure to cigarette smoke (CS) is associated with emphysema. In addition to chronic lung inflammation, emphysema is known mainly for the complex pathogenesis associated with imbalance of proteol...
|
Yan Zhou,
Xianshu Tan,
Wenjuan Kuang,
Litao Liu,
Lihong Wan
et al.
|
Full-length article
(In Press Uncorrected Proof)
|
24 October 2011 |
|
Inflammatory bowel disease: role of diet, microbiota, life style
DOI: 10.1016/j.trsl.2011.09.001
Inflammatory bowel disease (IBD) encompassed several chronic inflammatory disorders leading to damage of the gastrointestinal tract (GI). The 2 principal forms of these disorders are ulcerative coliti...
|
Manuela G. Neuman,
Radu M. Nanau
|
Review article
(In Press Uncorrected Proof)
|
26 September 2011 |
|
Metabolome and inflammasome in inflammatory bowel disease
DOI: 10.1016/j.trsl.2011.08.006
Inflammatory bowel disease (IBD) encompasses several chronic inflammatory disorders leading to the damage of the gastrointestinal tract. The 2 principal forms of these disorders are ulcerative colitis...
|
Radu M. Nanau,
Manuela G. Neuman
|
Review article
(In Press Uncorrected Proof)
|
16 September 2011 |